BSF-2 is not just a differentiation factor

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The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells

The role of recombinant B cell stimulatory factor 2 (BSF-2/IL-6) in the regulation of growth and differentiation of B cells was investigated. rBSF-2 at 200 pg/ml could induce 50% of the maximum Ig production in B lymphoblastoid cell lines, the specific activity being estimated as 5 X 10(6) U/mg. rBSF-2 augmented PWM-induced IgM, IgG, and IgA production in mononuclear cells (MNC); the effect was...

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ژورنال

عنوان ژورنال: Nature

سال: 1986

ISSN: 0028-0836

DOI: 10.1038/324415a0